"For the record, I am not pregnant. What I am is fed up," writes the former F.R.I.E.N.D.S star.
About the 'sport-like scrutiny and body-shaming,' Ms Aniston writes: "Is she pregnant? Is she eating too much? Has she let herself go? Is her marriage on the rocks because the camera detects some physical "imperfection"?"
"We are complete with or without a mate, with or without a child" - Jennifer Aniston's words have reverberated across social media.
Here's some of what Twitter is saying.
Many are cheered by and are cheering Ms Aniston's blistering piece.
Jennifer Aniston has proved once again that she's too good for this world.
— Cristina (@anistonsdaily) July 13, 2016
Jennifer Aniston,take a bow #Respect
— Onaiza (@Onaiza64) July 13, 2016
Jennifer Aniston is all of us pic.twitter.com/ydIJhBQ2dr
— jakeshaker (@Jakeshaker) July 13, 2016
jennifer aniston is my hero
— kate. (@kategxo) July 13, 2016
jennifer aniston is such an amazing role model, the world is so blessed
— cheyenne (@woahaniston) July 13, 2016
Some have cued the F.R.I.E.N.D.S quips.
When a fiery Greek temper is unleashed: Jennifer Aniston. pic.twitter.com/rucnN48vw6
— Costas Spanos (@CSpan22) July 13, 2016
After reading Jennifer Aniston's piece pic.twitter.com/wmDvw3mvOm
— Cupid or Cats (@janey_b_good) July 13, 2016
Jennifer Aniston wrote a huge essay after she wrote one to Ross, this woman is a pro both in reel and real life :D #JenniferAniston
— vasundhara bhatt (@BhattVowingsun) July 13, 2016
Others were truly not impressed.
What a great way to start a day by knowing that Jennifer Aniston is not pregnant. Like there's nothing else to talk about.
— Cristiano Chesi (@CristianoChesi) July 13, 2016
There is nothing new in Aniston's rant. Ageing woman who no longer benefits from system, lashes out at system. Tedious.
— Paddy (@Paddydwsn) July 13, 2016
owh I thought friends are reuniting again but it's just pregnancy rumours. meh
— An Ontre (@AnOntre) July 13, 2016
now Jennifer Aniston is fed up - and so are we.
Jennifer Aniston, who married Justin Theroux in 2015, played Rachel Green on F.R.I.E.N.D.S from 1994 to 2004. Since then, her films appearances have included The Break-Up, Marley & Me and Horrible Bosses. 2014's Cake fetched her nominations at the Golden Globe and SAG Awards.