It has been emphasized time and again how over consumption of alcohol can take a severe toll on your liver. According to a latest study, it may not spare your heart too. According to a latest study published in Journal of the American College of Cardiology, even moderate level of alcohol consumption may worsen the condition of heart failure patients with a faulty versions of a gene called titin.
The gene titin plays an instrumental role in maintaining the elasticity of the heart muscle. However a faulty version of the gene may cause dilated cardiomyopathy (DCM)-- a type of heart failure where the left ventricle becomes weak causing lessening the ability to pump blood.
"Our research strongly suggests alcohol and genetics are interacting -- and genetic predisposition and alcohol consumption can act together to lead to heart failure," said study co-author James Ware from the National Heart and Lung Institute at Imperial College London.
The study was conducted in parts. For the first part of the study, the team examined a total of 141 patients with a type of heart failure called alcoholic cardiomyopathy (ACM) -- a type of heart failure due to long term alcohol abuse which may trigger because of drinking more than 70 units a week (roughly seven bottles of wine) for five years or more.
The findings revealed that faulty titin gene may have played a role in aggravating the condition.
The findings showed that 13.5 per cent of ACM patients carried the mutation -- much higher than the proportion of people who carry them in the general population.
The researchers explained that condition is not simply the result of alcohol poisoning, but may from a genetic predisposition and thus can put other family members at risk as well. In other words, your progeny’s may have to suffer for your vice too.
It is imperative for relatives of patients with ACM should receive assessment and heart scans to see if they unknowingly carry the faulty gene, Ware noted.
In the second part of the experiment, the team analysed 716 patients with dilated cardiomyopathy - a condition that causes the heart muscle to become stretched and thin.
It was revealed that patients whose DCM was caused by the faulty titin gene, even moderately increased alcohol intake (defined as drinking above the weekly recommended limit of 14 units), affected the heart's pumping power.
"Alcohol and the heart have a complicated relationship. While moderate levels may have benefits for heart health, too much can cause serious cardiac problems. This research suggests that in people with titin-related heart failure, alcohol may worsen the condition," explained study co-author, Paul Barton from the National Heart and Lung Institute at Imperial.
(With Inputs IANS)
The gene titin plays an instrumental role in maintaining the elasticity of the heart muscle. However a faulty version of the gene may cause dilated cardiomyopathy (DCM)-- a type of heart failure where the left ventricle becomes weak causing lessening the ability to pump blood.
"Our research strongly suggests alcohol and genetics are interacting -- and genetic predisposition and alcohol consumption can act together to lead to heart failure," said study co-author James Ware from the National Heart and Lung Institute at Imperial College London.
The study was conducted in parts. For the first part of the study, the team examined a total of 141 patients with a type of heart failure called alcoholic cardiomyopathy (ACM) -- a type of heart failure due to long term alcohol abuse which may trigger because of drinking more than 70 units a week (roughly seven bottles of wine) for five years or more.
The findings revealed that faulty titin gene may have played a role in aggravating the condition.
The findings showed that 13.5 per cent of ACM patients carried the mutation -- much higher than the proportion of people who carry them in the general population.
The researchers explained that condition is not simply the result of alcohol poisoning, but may from a genetic predisposition and thus can put other family members at risk as well. In other words, your progeny’s may have to suffer for your vice too.
It is imperative for relatives of patients with ACM should receive assessment and heart scans to see if they unknowingly carry the faulty gene, Ware noted.
In the second part of the experiment, the team analysed 716 patients with dilated cardiomyopathy - a condition that causes the heart muscle to become stretched and thin.
It was revealed that patients whose DCM was caused by the faulty titin gene, even moderately increased alcohol intake (defined as drinking above the weekly recommended limit of 14 units), affected the heart's pumping power.
"Alcohol and the heart have a complicated relationship. While moderate levels may have benefits for heart health, too much can cause serious cardiac problems. This research suggests that in people with titin-related heart failure, alcohol may worsen the condition," explained study co-author, Paul Barton from the National Heart and Lung Institute at Imperial.
(With Inputs IANS)
