Type 1 diabetes is a chronic condition in which the pancreas' ability to produce insulin is hampered. If the findings of a latest study is to be believed, a vaccine which is primarily used for treating tuberculosis could prove to be effective in reducing high blood sugar among people with Type - 1 diabetes.Three years after receiving two administrations of the Bacillus Calmette-Guerin (BCG) vaccine four weeks apart, people with longstanding Type-1 diabetes showed an improvement in HbA1c - Aglycated haemoglobin - measured to test the overall sugar levels to near normal levels.
"This is clinical validation of the potential to stably lower blood sugars to near normal levels with a safe vaccine, even in patients with longstanding disease," said Denise Faustman, director of the Massachusetts General Hospital Immunobiology Laboratory, US.
For the study, the team of scientists analysed data from 282 human study participants - 52 with Type-1 diabetes who participated in the BCG clinical trials and 230 who contributed blood samples for mechanistic studies.
In the findings it was revealed that the HbA1c levels of those receiving BCG had dropped by more than 10 per cent in three years after treatment and by more than 18 per cent in four years.
The study published in the journal npj Vaccine, said that this BCG vaccination induces epigenetic reprogramming at the chromatin architecture level and functional alterations indicative of a permanent change in immunity.
The researchers are optimistic that the vaccine can have a lasting and valuable impact on the immune system.
Diabetes is fast emerging to be one of the most prevalent health concerns around the globe. While scientist across the globe are working hard to come up with a definitive cure to the disorder, delayed diagnosis and lack of awareness is making is extra hard to manage the condition. Not many would know that diet plays a crucial role in regulating your blood sugar levels.
1. Consume complex carbohydrates: A balanced diet is crucial to managing diabetes and one rich in complex carbs can do so effectively. Complex carbs are the ones rich in fibre and not processed.
3. Consume more nuts: Almonds, walnuts, cashews and pistachios are rich in vitamins and minerals, as well as good fat. Adding them to your diet may help preventing surge in blood sugar levels.
5. Do not skip breakfast: A high-energy breakfast is very essential to kick-start the metabolism and prevent sudden spikes in blood sugar levels.
"This is clinical validation of the potential to stably lower blood sugars to near normal levels with a safe vaccine, even in patients with longstanding disease," said Denise Faustman, director of the Massachusetts General Hospital Immunobiology Laboratory, US.
For the study, the team of scientists analysed data from 282 human study participants - 52 with Type-1 diabetes who participated in the BCG clinical trials and 230 who contributed blood samples for mechanistic studies.
In the findings it was revealed that the HbA1c levels of those receiving BCG had dropped by more than 10 per cent in three years after treatment and by more than 18 per cent in four years.
The study published in the journal npj Vaccine, said that this BCG vaccination induces epigenetic reprogramming at the chromatin architecture level and functional alterations indicative of a permanent change in immunity.
The researchers are optimistic that the vaccine can have a lasting and valuable impact on the immune system.
Diabetes is fast emerging to be one of the most prevalent health concerns around the globe. While scientist across the globe are working hard to come up with a definitive cure to the disorder, delayed diagnosis and lack of awareness is making is extra hard to manage the condition. Not many would know that diet plays a crucial role in regulating your blood sugar levels.
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1. Consume complex carbohydrates: A balanced diet is crucial to managing diabetes and one rich in complex carbs can do so effectively. Complex carbs are the ones rich in fibre and not processed.
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3. Consume more nuts: Almonds, walnuts, cashews and pistachios are rich in vitamins and minerals, as well as good fat. Adding them to your diet may help preventing surge in blood sugar levels.
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5. Do not skip breakfast: A high-energy breakfast is very essential to kick-start the metabolism and prevent sudden spikes in blood sugar levels.
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