People with anxiety fundamentally perceive the world differently, a new study has found. (Representational Image)
Jerusalem:
People with anxiety fundamentally perceive the world differently, a new study has found, suggesting that they are not able to distinguish between safe or dangerous situations.
The results show that people diagnosed with anxiety are less able to distinguish between a neutral, "safe" stimulus (in this case, the sound of a tone) and one that was earlier associated with the threat of money loss or gain.
In other words, when it comes to emotional experiences, they show a behavioral phenomenon known as over-generalisation, researchers said.
"We show that in patients with anxiety, emotional experience induces plasticity in brain circuits that lasts after the experience is over," said Rony Paz from Weizmann Institute of Science in Israel.
"Such plastic changes occur in primary circuits that later mediate the response to new stimuli, resulting in an inability to discriminate between the originally experienced stimulus and a new similar stimulus," he said.
"Therefore, anxiety patients respond emotionally to such new stimuli as well, resulting in anxiety even in apparently irrelevant new situations. Importantly, they cannot control this, as it is a perceptual inability to discriminate," he added.
For the study, researchers trained people with anxiety to associate three distinct tones with one of three outcomes - money loss, money gain, or no consequence.
In the next phase, participants were presented with one of 15 tonnes and were asked whether they had heard the tone before in training or not. If they were right, they were rewarded with money.
The best strategy was not to mistake (or over-generalise) a new tone for one they had heard in the training phase. But researchers found that people with anxiety were more likely than healthy controls to think that a new tone was actually one of the tones they had heard earlier.
That is, they were more likely to mistakenly associate a new tone with money loss or gain. Those differences were not explained by differences in participants' hearing or learning abilities. They simply perceived the sounds that were earlier linked to an emotional experience differently.
Functional magnetic resonance images (fMRIs) of the brains of people with anxiety versus healthy controls showed differences in brain responses, too.
Those differences were mainly found in the amygdala, a brain region related to fear and anxiety, and also in primary sensory regions of the brain. These results strengthen the idea that emotional experiences induce changes in sensory representations in anxiety patients' brains, researchers said.
The findings might help to explain why some people are more prone to anxiety than others, although the underlying brain plasticity that leads to anxiety isn't in itself "bad."
"Anxiety traits can be completely normal, and even beneficial evolutionarily. Yet an emotional event, even minor sometimes, can induce brain changes that might lead to full-blown anxiety," Paz said.
The findings were published in the journal Current Biology.
(This story has not been edited by NDTV staff and is auto-generated from a syndicated feed.)
The results show that people diagnosed with anxiety are less able to distinguish between a neutral, "safe" stimulus (in this case, the sound of a tone) and one that was earlier associated with the threat of money loss or gain.
In other words, when it comes to emotional experiences, they show a behavioral phenomenon known as over-generalisation, researchers said.
"We show that in patients with anxiety, emotional experience induces plasticity in brain circuits that lasts after the experience is over," said Rony Paz from Weizmann Institute of Science in Israel.
"Such plastic changes occur in primary circuits that later mediate the response to new stimuli, resulting in an inability to discriminate between the originally experienced stimulus and a new similar stimulus," he said.
"Therefore, anxiety patients respond emotionally to such new stimuli as well, resulting in anxiety even in apparently irrelevant new situations. Importantly, they cannot control this, as it is a perceptual inability to discriminate," he added.
For the study, researchers trained people with anxiety to associate three distinct tones with one of three outcomes - money loss, money gain, or no consequence.
In the next phase, participants were presented with one of 15 tonnes and were asked whether they had heard the tone before in training or not. If they were right, they were rewarded with money.
The best strategy was not to mistake (or over-generalise) a new tone for one they had heard in the training phase. But researchers found that people with anxiety were more likely than healthy controls to think that a new tone was actually one of the tones they had heard earlier.
That is, they were more likely to mistakenly associate a new tone with money loss or gain. Those differences were not explained by differences in participants' hearing or learning abilities. They simply perceived the sounds that were earlier linked to an emotional experience differently.
Functional magnetic resonance images (fMRIs) of the brains of people with anxiety versus healthy controls showed differences in brain responses, too.
Those differences were mainly found in the amygdala, a brain region related to fear and anxiety, and also in primary sensory regions of the brain. These results strengthen the idea that emotional experiences induce changes in sensory representations in anxiety patients' brains, researchers said.
The findings might help to explain why some people are more prone to anxiety than others, although the underlying brain plasticity that leads to anxiety isn't in itself "bad."
"Anxiety traits can be completely normal, and even beneficial evolutionarily. Yet an emotional event, even minor sometimes, can induce brain changes that might lead to full-blown anxiety," Paz said.
The findings were published in the journal Current Biology.
(This story has not been edited by NDTV staff and is auto-generated from a syndicated feed.)
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