Madrid:
Juanma Mata and Pablo Hernandez both scored in the second half as Valencia beat 10-man Sevilla 2-0, while Roberto Soldado scored a hat-trick as Getafe romped to a 4-1 win over Racing Santander to open its campaign.
Mata collected teammate Ever Banega's controlled pass in the 47th minute and struck the ball through a crowed area and beyond goalkeeper Andres Palop to open the scoring before Hernandez sealed the victory in the 80th with a looping volley on Sunday.
Sevilla had lost Frederic Kanoute at the end of the first half when the Mali striker received a second yellow card for a challenge on Carlos Marchena. The scoreline would have been more lopsided but for Palop, who made a number of impressive saves to keep Sevilla in the game.
Striker Alvaro Negredo made his debut for Sevilla following a transfer from Real Madrid last week, coming on in the second half when coach Manolo Jimenez also brought on striker Arouna Kone in a vain bid to bolster his attack.
Elsewhere, Malaga defeated Atletico Madrid 3-0, Athletic Bilbao won 1-0 against Espanyol, Mallorca bested Xerez 2-0, Osasuna drew 1-1 with Villarreal and Almeria and 10-man Valladolid played out a 0-0 draw.
In Santander, Rafael Lopez opened the scoring for Getafe in the 12th minute after heading home Adrian Gonzalez's corner. Gonzalez set up Soldado's first, a close-range shot in the penalty area in the 29th and the forward stretched the lead with his second five minutes later.
Santander midfielder Mehdi Lacen pulled one back in the 43rd minute but Soldado completed his hat trick in the 56th minute.
Atletico started badly when coach Abel Resino was ejected for vocally objecting a decision and Malaga went on to score from only five occasions in the searing heat, with temperatures reaching 38 degrees Celsius.
Nabil Baha scored with an athletic overhead bicycle shot from an assist by Duda in the 34th and Manuel Torres scored from a corner in the 62nd. Malaga's midfielder Xavi Torres got the third goal in the 89th minute.
Atletico's Raul Garcia had to leave the field with an injury that was believed to be a fracture in a foot, radio network Cadena Ser reported.
Xerez defender Leandro Gioda was ejected in the 42nd minute for a second yellow card after he handled the ball in the penalty area.
Mallorca's Aritz Aduriz scored in the 57th minute and then supplied Antoni Adrover who scored with a left-footed shot in the 60th minute.
Villarreal's Santiago Cazorla surprised Osasuna's defense in the 33rd minute and Uruguay international Walter Pandiani equalized in the 37th minute.
Athletic Bilbao forward Gaizka Toquero beat Espanyol goalkeeper Carlos Kameni in the 78th minute to score.
Cristiano Ronaldo was on target with a penalty to help lead Real Madrid to a 3-2 victory over Deportivo La Coruna on Saturday, when Zaragoza beat Tenerife 1-0.