ICMR Has A New Report On Mix-And-Match Vaccines: The Way Forward

A preprint study by NIV Pune has suggested that a mix of Covishield and Covaxin may give better results. Other global studies have focused on mixing mRNA vaccines (Pfizer and Moderna) with an Adenovirus-based vaccine (Astrazeneca). However, these global trials have been too small to test effective combinations or pick up rare events such as clotting. Large-scale efficacy studies are becoming difficult, while two different vaccines may have their own profile of adverse events and effects. We seek the opinion of leading experts and analyse the challenges.