Dengue DENV-2 is known to be the most virulent strain and can cause severity in disease. Dengue has four serotypes - DENV-1, DENV-2, DENV-3 and DENV-4 - which means that dengue can potentially infect an individual four times. If protective measures against vector-borne diseases are not taken, then it can lead to complications and death. DENV-2 causes severe symptoms in infected patients and it is important that the people notice the warning signs and consult a doctor.