The domestic stock markets started Tuesday's session on a negative note amid mixed global cues. The S&P BSE Sensex opened at 34,068.92 against its previous close of 34,067.40. The broader Nifty50 index started at 10,239.40 as compared to the last close of 10,250.85. In the first few minutes of trade, the 30-share Sensex traded at 33,958.57, down 108.83 points or 0.32 per cent, and the 50-scrip Nifty was at 10,208.45, with a loss of 42.40 points or 0.41 per cent.