Study Discovers Why Some People Don't Get Covid

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22 June 2024

Researchers discovered why some people never get Covid-19 through a novel immune response analysis


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The study was led by the Wellcome Sanger Institute and University College London in the UK


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Researchers analyzed genetic activity in nasal tissues and blood of people with unsuccessful SARS-CoV-2 infections


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Sixteen unvaccinated volunteers were intentionally infected with a pre-Alpha strain under strict laboratory conditions


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Single-cell RNA sequencing provided detailed timelines on hundreds of thousands of individual cells' activity


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Three infection categories were identified: transient, sustained, and abortive, revealing the body's secret weapon


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Volunteers with abortive infections showed faster immune reactions in nasal tissues, clearing the virus quickly


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Elevated expression of the gene HLA-DQA2 in nasal cells was linked to mild infections


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These findings highlight crucial early immune responses that either clear the virus or allow infection


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Understanding these responses could help develop treatments and vaccines mimicking these natural protective mechanisms


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