Washington:
Scientists, including one of Indian-origin, have turned a small, US $40 needle into a 3D microscope capable of taking images up to 70 times smaller than the width of a human hair.
A new method developed by a University of Utah research team not only produces high-quality images comparable to expensive microscopes, but may be implanted into the brains of living mice for imaging at the cellular level.
Designed by Rajesh Menon, an associate professor of electrical and computer engineering, and graduate student Ganghun Kim, the microscope technique works when an LED light is illuminated and guided through a fibre-optic needle or cannula.
Returned pictures are reconstructed into 3D images using algorithms developed by Menon and Kim.
"Unlike miniature microscopes, our approach does not use optics. It's primarily computational," Menon said.
He said this approach will allow researchers not only to take images far smaller than those taken by current miniature microscopes, but do it for a fraction of the cost.
"We can get approximately 1-micron-resolution images that only US $250,000 and higher microscopes are capable of generating. Miniature microscopes are limited to the few tens of microns," Menon said.
Menon hopes to extend the technology in the future so it can see details down to sub-micron resolutions, compared with the current 1.4 microns.
The microscope was originally designed for the lab of Nobel Prize-winning professor, Mario R Capecchi, whose team will use it to observe the brains of living mice to gain insight into how certain proteins in the brain react to various stimuli.
Menon and Kim expect many other uses for the device since it can be assembled so inexpensively and easily go into hard-to-reach places.
"This microscope will open up new avenues of research," Menon said.
"Its low-cost, small-size, large field-of-view and implantable features will allow researchers to use this in fields ranging from biochemistry to mining," said Menon.
The study appears in the journal Applied Physics Letters.
A new method developed by a University of Utah research team not only produces high-quality images comparable to expensive microscopes, but may be implanted into the brains of living mice for imaging at the cellular level.
Designed by Rajesh Menon, an associate professor of electrical and computer engineering, and graduate student Ganghun Kim, the microscope technique works when an LED light is illuminated and guided through a fibre-optic needle or cannula.
Returned pictures are reconstructed into 3D images using algorithms developed by Menon and Kim.
"Unlike miniature microscopes, our approach does not use optics. It's primarily computational," Menon said.
He said this approach will allow researchers not only to take images far smaller than those taken by current miniature microscopes, but do it for a fraction of the cost.
"We can get approximately 1-micron-resolution images that only US $250,000 and higher microscopes are capable of generating. Miniature microscopes are limited to the few tens of microns," Menon said.
Menon hopes to extend the technology in the future so it can see details down to sub-micron resolutions, compared with the current 1.4 microns.
The microscope was originally designed for the lab of Nobel Prize-winning professor, Mario R Capecchi, whose team will use it to observe the brains of living mice to gain insight into how certain proteins in the brain react to various stimuli.
Menon and Kim expect many other uses for the device since it can be assembled so inexpensively and easily go into hard-to-reach places.
"This microscope will open up new avenues of research," Menon said.
"Its low-cost, small-size, large field-of-view and implantable features will allow researchers to use this in fields ranging from biochemistry to mining," said Menon.
The study appears in the journal Applied Physics Letters.
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