Beijing: Scientists have discovered the key gene behind severe malaria, a finding that may provide new strategies for the treatment and prevention of the deadly disease.
The discovery, published in Nature magazine on Sunday by experts from China, France, Denmark and Germany, pointed out that the antigenic variation of the Plasmodium falciparum multicopy var gene family is the key gene linked to severe malaria.
It found that expression of a particular var subgroup called "upsA," is what causes human cerebral malaria, a severe malaria, state-run Xinhua news agency reported.
The scientists observed an inverse relationship between transcript levels of PfRNase II and upsA-type var genes, which implied a key role of PfRNase II in severe malaria.
Malaria is one of the oldest infectious diseases. Severe malaria claims the lives of about a million people in the world annually. PTI
The discovery, published in Nature magazine on Sunday by experts from China, France, Denmark and Germany, pointed out that the antigenic variation of the Plasmodium falciparum multicopy var gene family is the key gene linked to severe malaria.
It found that expression of a particular var subgroup called "upsA," is what causes human cerebral malaria, a severe malaria, state-run Xinhua news agency reported.
The scientists observed an inverse relationship between transcript levels of PfRNase II and upsA-type var genes, which implied a key role of PfRNase II in severe malaria.
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Malaria is one of the oldest infectious diseases. Severe malaria claims the lives of about a million people in the world annually. PTI
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